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Author: Louise Stanley

BHP’s health inequality lead set to head up NIHR Challenge Maternal Disparities Consortium

Written by Louise Stanley on . Posted in Birmingham Health Partners, Health inequalities, Maternal health.

Professor Joht Singh Chandan – BHP’s heath inequalities lead and Clinical Professor of Public Health at the University of Birmingham – has been announced as co-lead of a new consortium which will research inequalities faced by expectant and new mothers.

The new NIHR Challenge Maternity Disparities Consortium is led by nine UK universities, all aiming to tackle inequalities in maternity care while building capacity for further research to help improve services over time. The consortium will help support professionals who plan and deliver services for women and babies across both health and social care.

Professor Chandan said: “I am honoured to take on the role of co-lead for the NIHR Maternity Disparities Consortium. Tackling inequalities in maternity care is a critical priority, and this consortium brings together a wealth of expertise to drive meaningful change.

“Our goal is to address disparities before, during, and after pregnancy by focusing on research that leads to real improvements in care for families and their babies across the UK. I am particularly looking forward to learning from and working alongside the communities most affected by these inequalities, ensuring that their insights shape our work and lead to lasting, impactful solutions.”

Professor Chandan will be joined by co-lead Dr Victoria Hodgetts Morton from the University of Birmingham, Dr Beck Taylor from Warwick University, Professor Will Parry-Smith from Keele University and Dr Marion Gibbon from Birmingham City Council.

Professor William Parry-Smith, Professor of Obstetrics and Gynaecology at Keele University, said: “I’m pleased to be leading Keele’s contribution to this nationally important work. Research and capacity building undertaken by the consortium will tackle the problem of maternity disparities. We have the opportunity in the West Midlands to understand and to then make a real difference crucially to improving maternity outcomes.”

Dr Beck Taylor, Clinical Associate Professor in Public Health, University of Warwick said: “This new consortium is an unparalleled opportunity to tackle the persistent maternity inequalities affecting life chances across the UK. These unacceptable differences are felt particularly by communities in our own region, the West Midlands. This consortium the first of its kind, and we cannot wait to get started on this programme. As part of the consortium we’ll bring together the communities, professionals and researchers to drive the change that women, babies and society urgently needs.”

Professor Marian Knight, Scientific Director for NIHR Infrastructure, said: “We are delighted by the level of engagement shown by researchers with this important research priority. I am confident we have an exceptional consortium to tackle the challenge of maternity inequalities; working in partnership with existing NIHR funded infrastructure and programmes. We look forward to working with the consortium and their collaborators across the UK to develop the final plans for their ground-breaking new research projects over the next few months.”

Health Minister Baroness Gillian Merron said: “Every woman should receive safe, personalised and compassionate maternity care, regardless of background. We are determined to tackle the stark and unacceptable inequalities in maternity services and are working with NHS England to urgently improve care. Government-funded research like this is crucial to driving positive change.

“This is part of our mission to build an NHS fit for the future by harnessing the full potential of our research and life sciences sector.”

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One year in: Birmingham Health Partners drives progress in reducing bureaucracy in clinical trials

Written by Louise Stanley on . Posted in Birmingham Health Partners, Clinical trials.

Birmingham Health Partners (BHP) is marking a year of transformative work on its Reducing Bureaucracy in Clinical Trials programme, which launched in November 2023 with the aim of establishing Birmingham a leader in delivering cutting-edge clinical research more efficiently. The ambitious initiative was established in response to the national drive for innovation, as outlined in the Lord O’Shaughnessy and Tickell reviews.

A year in, the programme has made significant progress toward streamlining clinical trial processes and developing pragmatic solutions, with active participation from our partner organisations. focusing on areas such as grants, contracting and site setup. Work is ongoing to: develop tools to help researchers navigate the complex research landscape more effectively, including piloting an e-request form; standardise template agreements across the partnership and establish standard operating procedures (SOPs) for pre-award grants; and create a consistent NHS-academic costing model.

Amy Smith, Senior Programme Lead, said: “This first year has been about laying a strong foundation for transforming how clinical trials are delivered across Birmingham. We’re particularly appreciative of the 100+ individuals who submitted responses to our survey over the summer, allowing us to understand the researcher experience and tailor our programme accordingly.

“By working collaboratively, we are making real progress in reducing the administrative burden on researchers and getting vital innovations to our patients faster. We’re excited to see what the next year brings as we continue to refine and expand this work – starting with a report on the results of our survey which we will be publishing soon, and a Town Hall event where investigators and researchers can learn more about our programme, ask questions and share their thoughts.”

Register for the online Town Hall event – Monday 9 December at 2.30pm – at the following link: https://forms.office.com/e/4Tu7Q4u1pg

This initiative comes at a pivotal time, with Lord Darzi’s independent investigation underscoring the essential role of research in preparing the NHS for the future and the newly elected Labour Government setting out bold ambitions for the NHS – including speeding up clinical trial recruitment, improving diversity, and reducing the time it takes to introduce high-impact innovations to patients. Other reforms aim to move away from hospital care to more services delivered in the community, digitising healthcare, and prioritising prevention rather than focusing only on treating illness.

At a national level, the Health Research Authority (HRA) has made strides by meeting or exceeding targets for trial setup times, and the transition from Clinical Research Networks (CRNs) to Research Delivery Networks (RDNs) on October 1st marked a shift towards research in broader health and care settings. Despite these advances, national performance indicators suggest there is still progress to be made, particularly in commercial trial setups and recruitment of first patients.

BHP remains committed to transforming Birmingham’s healthcare through high-impact innovation – delivering research that matters to patients.

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Most accurate ultrasound test could detect 96% of ovarian cancers

Written by Louise Stanley on . Posted in Cancer outcomes, Early diagnosis and detection.

An ultrasound test that detected 96% of ovarian cancers in postmenopausal women should replace the current standard of care test in the UK, according to a new study by BHP members.

In a paper published in Lancet Oncology, researchers funded by the NIHR and led by Professor Sudha Sundar conducted a head-to-head comparison of all currently-available tests to diagnose ovarian cancer in postmenopausal women, in a high-quality diagnostic test accuracy study.

Of the six diagnostic tests investigated, the IOTA ADNEX model which looks at ultrasound features (how the lump looks on ultrasound) had the best accuracy of all and could detect up to 96% of ovarian cancers.

The ultrasound test outperforms the current standard of care in the UK significantly and so researchers recommend that the IOTA ultrasound ADNEX model should replace the current standard of care test in the UK which identifies 83% of ovarian cancers.

Sudha Sundar, Professor of Gynaecological Cancer at the University of Birmingham and consultant in gynaecological cancer surgery at Sandwell and West Birmingham NHS Trust – both BHP members – said: “This is the first time that a head-to-head study of all available ovarian cancer tests has been done in the same population. Here we studied their use with symptomatic, post-menopausal women who are most at risk of this cancer. Our trial found that the IOTA ADNEX ultrasound protocol had highest sensitivity for detecting ovarian cancer compared to the standard of care and other tests.

“The ultrasound test also performs well when delivered by a trained sonographer who has received specific training, certification and quality assurance, and as the vast majority of ultrasound scans are performed by sonographers it is important that a new standard is able to be delivered by as many clinical professionals as possible.

“We found that the higher sensitivity of the IOTA ADNEX model is likely to lead to some women who don’t have cancer also being flagged up as having a higher risk of cancer. We however did discuss this extensively with patients, cancer charity Target ovarian cancer and NHS experts who all agreed that in postmenopausal women who are at higher risk of ovarian cancer, picking up more women with cancer would benefit women overall.”

Annwen Jones OBE, Chief Executive at Target Ovarian Cancer said: “Early diagnosis of ovarian cancer is vital, and we are pleased to see this research demonstrate that there are more accurate ways of using ultrasound. The faster and earlier ovarian cancer is diagnosed, the easier it is to treat and the more successful the outcomes. Alongside this innovative research, we need to see greater awareness of the symptoms of ovarian cancer so that women know to come forward to their GP for testing and receive the best possible treatment as quickly as possible. It is crucial that new ways of working like this are rolled out as quickly as possible.”

The research team note that the IOTA ADNEX model achieved 96% accuracy when delivered by NHS sonographers who were appropriately trained and received quality assurance. As most scans worldwide are carried out by sonographers rather than gynaecologists, introductory free online resources have been created by the researchers for NHS staff to undergo the specialist ultrasound training to obtain certification and quality assurance.

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Birmingham opens Europe’s first pancreatic cancer mRNA vaccine trial

Written by Louise Stanley on . Posted in Cancer outcomes, Clinical trials, Experimental medicine.

Researchers at BHP founding-members University Hospitals Birmingham NHS Foundation Trust (UHB) and the University of Birmingham have opened a trial to study how messenger RNA (mRNA) cancer vaccines may be used to prevent recurrence of pancreatic cancer. The Queen Elizabeth Hospital Birmingham (QEHB) is the first hospital in Europe to recruit into such a trial.

Pancreatic cancer is among the deadliest cancers globally, with a survival rate beyond 10 years of just 5% in England (2013-2017). It is often only when the cancer has reached an advanced stage that physical symptoms appear, at which point it becomes more difficult to treat.

The trial aims to recruit patients undergoing surgery to remove pancreatic ductal adenocarcinoma (PDAC), an extremely aggressive disease that accounts for 90% of all pancreatic cancers.

Patients enrolled in the study will either receive an investigational cancer vaccine combined with chemotherapy (treatment group) or standard chemotherapy alone (control group).

In this investigational therapeutic cancer vaccine, mRNA is used to deliver the instructions for building several proteins (neoantigens) found in a person’s cancer. In doing so, the trial vaccine aims to train the immune system to recognise and attack the set of proteins (usually found on microscopic cancer cells) when it encounters it again.

Following surgery, samples of the patients’ tumour tissue and blood are sent to laboratories, to design and manufacture the investigational cancer vaccine. For the patients eligible for the trial, a mRNA-based cancer treatment is manufactured with mRNA specific to the proteins in that individual’s tumour.

This novel treatment approach is aimed at training the immune system to recognise and attack cancer cells, to potentially prevent cancer recurrence and increase the prospect of a patient being cured.

Dr Shivan Sivakumar, Principal Investigator of the trial, Associate Professor in Oncology at the University of Birmingham and Consultant Medical Oncologist at QEHB said: “We are incredibly proud that the Queen Elizabeth Hospital Birmingham is the first site in Europe to enrol a patient to this investigational pancreatic cancer vaccine trial. This achievement highlights Birmingham’s leading role in advancing cancer treatment, offering new hope for patients battling one of the most challenging cancers we face today.

“We recently also became the first site in Europe to open an immunotherapy study in cholangiocarcinoma (bile duct cancer), another deadly cancer. Birmingham is positioning itself to be a leading centre in Europe to test novel treatments for these hard-to-treat cancers and I find it humbling that patients in the Midlands have been able to enrol onto this trial, before anyone else in Europe.”

Professor Kiran Patel, Chief Medical Officer at UHB, which operates QEHB, added: “We are very fortunate to have exceptional infrastructure and world-class talent that positions us perfectly to lead in vital areas of cancer research.

“This trial showcases the expertise and dedication of our medical professionals, and the fantastic teams supporting them, who are at the leading edge of clinical research here in Birmingham.

“To be the first site to open in Europe, reaffirms our role as a national and international centre for cutting-edge oncology and highlights our commitment to improving patient outcomes through pioneering approaches.”

Jo Gray, Head of Research and Development Operations at UHB, said: “Through the National Institute for Health and Care Research (NIHR) Wellcome Trust Clinical Research Facility (CRF), we are able to provide expert care to patients receiving experimental therapies. Birmingham is the first site outside of North America to open and to enrol a patient onto this complex, early phase trial, that addresses an important need to identify better post-surgery treatments for pancreatic cancer.”

Professor Neil Hanley, Head of the College of Medical and Dental Sciences at the University of Birmingham, said: “This work epitomises why the University of Birmingham and its tremendous partnership with UHB is delivering life-changing impacts.

“Whilst such approaches were being investigated before 2020, we now know the power of mRNA vaccines from the COVID-19 pandemic; to tilt those discoveries from a time of tremendous challenge towards a much-needed world of new cancer treatments is inspiring for all of us.

“Birmingham is the ideal place to open this trial, with one of the leading pancreatic cancer units in the UK and serving a super diverse population. The chemistry between the university and hospitals is clear. By working as one team under the banner of Birmingham Health Partners, we are delivering the kind of cutting-edge research leading to transformational clinical care that befits Birmingham as an innovative city at the forefront of health and life sciences.”

Dr Chris Macdonald, Head of Research at Pancreatic Cancer UK, said: “For too long we have had so few treatment options for people with pancreatic cancer. Surgery is currently the only potential cure and yet, tragically, in 75% of cases the cancer reoccurs within a year. Finally, there is hope on the horizon.

“We are absolutely delighted that Queen Elizabeth Hospital Birmingham is the first site in Europe to enrol a patient to an individualised pancreatic cancer vaccine trial. We will be following the results with great interest, as the potential here cannot be understated. If this research proves successful, the vaccine could be a vital new weapon against the deadliest common cancer.”

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Birmingham Health Partners Centre for Regulatory Science and Innovation director appointed

Written by Louise Stanley on . Posted in Birmingham Health Partners.

Leading AI healthcare expert Professor Alastair Denniston has been appointed Director of the Birmingham Health Partners Centre for Regulatory Science and Innovation (BHP-CRSI).

Professor Denniston, who is Professor of Regulatory Science and Innovation at BHP founder-member the University of Birmingham brings a wealth of experience and expertise to his new role, having established himself as a leader in digital health and artificial intelligence-enabled medical technologies.

His team’s pioneering research in medical imaging and artificial intelligence (AI) applications in healthcare has attracted international acclaim, positioning him at the forefront of medical innovation.

Professor Neil Hanley, Head of the College of Medicine and Health at the University of Birmingham and Executive Director of Birmingham Health Partners said: “We are delighted to welcome Professor Denniston as the Director of BHP-CRSI. His vision and leadership will be instrumental in driving forward our agenda to drive innovation in regulatory science to promote efficient, safe and cost-effective implementation of new therapies, for the benefit of patients and society.”

Established in 2020 under the leadership of Professor Mel Calvert, BHP-CRSI serves as a collaborative hub for regulatory science and innovation, bringing together academia, industry, regulators, healthcare providers and patients. BHP-CRSI experts work with UK and international health regulators, using scientific and analytical skills to help optimise the regulatory process itself and accelerate innovation that can improve patient care.

The Centre’s activity is broadly grouped into three pillars: policy development; research and innovation; and capacity building and education. This helps ensure that innovation can be both effective and efficient, ensuring patient safety whilst also ensuring that patients can benefit from the best medicines and health technologies. The Centre has internationally-recognised expertise in critical areas such as AI, patient-reported outcomes, diagnostic tests, real world evidence and clinical trials.

Alastair Denniston

Professor Alastair Denniston, Professor of Regulatory Science and Innovation at the University of Birmingham and Honorary Consultant Ophthalmologist at BHP founder-members University Hospitals Birmingham (UHB) said: “I am honoured to lead BHP-CRSI and contribute to Birmingham Health Partners’ mission of improving patient outcomes through innovation. Together with our partners across the healthcare ecosystem, we will strive to create a supportive environment for regulatory science research and innovation, ultimately benefiting patients locally and globally.”

Prof Denniston’s appointment comes at an exciting time for the BHP-CRSI, with a number of its experts having been awarded UK Government funding to explore the creation of national Regulatory Science and Innovation Networks in high priority areas, including in AI and Digital HealthTech (led by Associate Professor Xiaoxuan Liu and Prof Denniston) and Advanced Therapies (led by Dr Olalekan Lee Aiyegbusi and Prof Mel Calvert, working with the Cell & Gene Therapy Catapult Ltd).

Prior to being appointed Director, Professor Denniston was the AI Theme Lead for BHP-CRSI and Director of the INSIGHT Health Data Hub for Eye Health, spearheading initiatives that continue to transform healthcare policies in data, digital health and artificial intelligence. He continues in his role as Member of the Regulatory Horizons Council to the UK Government, and as an NHS clinician at UHB.

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